ArticleiScience2026
Hippocampal ERK2 dimerization regulates inhibitory avoidance memory reconsolidation and synaptic plasticity.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- The pERKs of temporal order memory in mice.Frontiers in molecular neuroscience · 2026Article
- Identification and Characterization of ERK2 Dimerization Inhibitors by Integrated In Silico and In Vitro Screening.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extensive research has examined extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in memory and synaptic plasticity, yet the mechanisms linking ERK activity to memory stabilization remain unclear. ERK dimerization is required for the activation of cytoplasmic targets involved in plasticity. Here, we investigated the role of ERK2 dimerization in long-term memory reconsolidation and synaptic plasticity. Reactivation of weak inhibitory avoidance (wIA) memory significantly reduced hippocampal ERK2 dimerization. Post-reactivation, intrahippocampal infusion of the ERK dimerization inhibitor DEL-22379 (DEL) produced bidirectional effects, impairing reconsolidation of strong inhibitory avoidance (sIA) memory, while enhancing reconsolidation of wIA memory. DEL administration efficiently blocked hippocampal ERK2 dimerization and impaired maintenance of high-frequency stimulation-induced long-term potentiation (LTP) in the hippocampal slices. These findings demonstrate that ERK2 dimerization occurs in the intact mouse brain and plays a critical role in IA memory and synaptic plasticity, highlighting its relevance in memory reconsolidation processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.