Evidence map›Paper›PMID 42437004›Full record

ArticleiScience2026

Light-activated insulin receptor modulates neuronal plasticity and cerebellar-driven behavior.

Bianca Preissing, Franziska Sackel, Marija Trajkovic-Arsic, Lennard Rohr, Anna-Lena Linke, Melanie Bewerunge-Hudler, Sven-Thorsten Liffers, Jens Thomas Siveke, Stefan Herlitze, Ida Siveke

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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bianca PreissingDepartment of Zoology and Neurobiology, Ruhr-University Bochum, 44780 Bochum, Germany.
Franziska SackelDepartment of Zoology and Neurobiology, Ruhr-University Bochum, 44780 Bochum, Germany.
Marija Trajkovic-ArsicBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, 445147 Essen, Germany.
Lennard RohrDepartment of Zoology and Neurobiology, Ruhr-University Bochum, 44780 Bochum, Germany.
Anna-Lena LinkeDepartment of Zoology and Neurobiology, Ruhr-University Bochum, 44780 Bochum, Germany.
Melanie Bewerunge-HudlerMicroarray-Core Facility, German Cancer Research Center, DKFZ, 69120 Heidelberg, Germany.
Sven-Thorsten LiffersBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, 445147 Essen, Germany.
Jens Thomas SivekeBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, 445147 Essen, Germany.
Stefan HerlitzeDepartment of Zoology and Neurobiology, Ruhr-University Bochum, 44780 Bochum, Germany.
Ida SivekeDepartment of Zoology and Neurobiology, Ruhr-University Bochum, 44780 Bochum, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have developed an optogenetic tool called InLOV-an insulin receptor fused to a LOV domain-that enables activation of the insulin receptor signaling pathway via light-induced phosphorylation of its intracellular domains. Light activation of InLOV promotes insulin-induced neuronal plasticity in the mouse cerebellum and enhances cerebellar-driven self-motion behavior. Thus, InLOV enables optogenetic modulation of insulin receptor phosphorylation, opening new possibilities for disease modeling and therapeutic strategies for pathological insulin signaling in humans.

Indexed as

behaviorcerebelluminsulin signalingneuronal plasticityoptogenetics

Identifiers

PMID42437004
PMCPMC13355479

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.