ArticleBiochemistry and biophysics reports2026
TRP matters: a pilot study on expression of mRNA in the parotid glands and their benign tumors.
Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The transient receptor potential (TRP) channels are a group of nonselective cation channels, which play critical roles in a variety of physiological processes and are also involved in the development of various carcinomas. However, the presence of TRP channels and their role in human benign salivary gland tumors has not been investigated yet. Methods: We assessed the mRNA expression of the TRP channels TRPA1, TRPC3, TRPC6, TRPM4, TRPM8 as well as the channel associated factors TCAF1 and TCAF2 in human specimens of pleomorphic adenoma (PA, n = 10) and Warthin tumors (WT, n = 10) of the parotid gland. The control group consisted of 5 healthy human parotid gland (PG) specimens. The analysis has been performed using qRT-PCR. Results: The mRNAs of TRPM4, TRPC6, TCAF1 and TCAF2 were found in normal parotid gland tissue and even more pronounced in PA and WT. However, no mRNA of TRPA1, TRPC3 and TRPM8 could be detected in normal parotid tissue nor in WT. In contrast, TPRC3 and TRPM8 mRNA were detected in PA. In 4 out of 10 PA high mRNA expression levels were found for these two genes. Conclusion: Our current pilot study suggests that TRPM4, TRPC6, TCAF1 and TCAF2 are expressed in normal parotid gland tissue and partially elevated in PA as well as WT of the parotid gland. TRPC3 and TRPM8 seem to be restricted to PA and may be highly expressed in a subgroup of parotid gland PA. These findings are important for a better understanding of PA biology.
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