Evidence map›Paper›PMID 42437177›Full record

ArticleRegenerative biomaterials2026

A self-oxygenating polyphenol-nanozyme hydrogel remodels the inflammatory microenvironment for diabetic wound healing.

Shangqing Huang, Yujia Zheng, Shengxi Jiang, Huabin Liu, Lijun Tang, Chaoming Xie, Jie Weng, Yanan Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shangqing HuangKey Laboratory of Advanced Technologies of Materials Ministry of Education, Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Yujia ZhengKey Laboratory of Advanced Technologies of Materials Ministry of Education, Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Shengxi JiangKey Laboratory of Advanced Technologies of Materials Ministry of Education, Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Huabin LiuKey Laboratory of Advanced Technologies of Materials Ministry of Education, Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Lijun TangKey Laboratory of Advanced Technologies of Materials Ministry of Education, Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Chaoming XieKey Laboratory of Advanced Technologies of Materials Ministry of Education, Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Jie WengKey Laboratory of Advanced Technologies of Materials Ministry of Education, Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.ORCID https://orcid.org/0000-0002-7034-3215
Yanan JiangObesity and Metabolism Medicine-Engineering Integration Laboratory, Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu 610031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wounds are characterized by prolonged hyperglycemia and associated hypoxia, induce oxidative stress and sustained inflammation, which collectively impair angiogenesis and hinder the healing process. Conventional oxygen‑supplying hydrogel dressings are often limited by inefficient oxygen release, poor stability, and insufficient multifunctionality. To overcome these limitations, we have designed a GelMA-MnPZC multifunctional nanocomposite hydrogel dressing capable of stable and prolonged oxygen release. This hydrogel remodels the hypoxic and inflammatory wound microenvironment through sustained oxygen generation and polyphenol‑mediated activity, thereby creating favorable conditions for angiogenesis and tissue regeneration. The hydrogel was fabricated by embedding polydopamine-manganese (PDA-Mn) nanozyme‑modified, ZIF‑8‑encapsulated CaO

Indexed as

diabetic wound healingimmunomodulatory hydrogelspolyphenol-nanozymeself-oxygenating

Identifiers

PMID42437177
PMCPMC13355597

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.