ArticleAmerican heart journal plus : cardiology research and practice2026
Assessment of lipid profile abnormalities and associated biochemical markers among cardiovascular disease patients in Hajjah Governorate, Yemen: A case-control study.
Article in American heart journal plus : cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cardiovascular diseases (CVDs) remain a leading cause of morbidity in Yemen. This study evaluates integrated lipid, renal, and hepatic function profiles in CVD patients to provide clinical insights into multi-organ metabolic associations in a resource-limited setting. Methods: This hospital-based, case-control study at Al-Gomhouri Hospital, Hajjah, Yemen, enrolled 320 participants (160 CVD patients and 160 age- and sex-matched controls). Assessments included lipid profiles, renal markers (uric acid, creatinine), and hepatic markers (albumin, total protein). Multivariate logistic regression identified factors associated with CVD status. Results: CVD patients exhibited severe atherogenic dyslipidemia, with significantly higher Total Cholesterol (269.7 ± 43.83 mg/dL) and Triglycerides (246.0 ± 58.97 mg/dL) than controls ( Conclusion: Significant alterations in cardiorenal and hepatic biomarkers characterize CVD patients in Hajjah. Stage 2 hypertension, hyperuricemia, and elevated creatinine are critical metabolic factors, highlighting the necessity of integrated multi-organ biochemical screening over isolated lipid assessments for improved risk stratification in high-risk populations.
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