Evidence map›Paper›PMID 42437701›Full record

ArticleChemMedChem2026

Structure-Activity Relationship Analysis and hERG Liability Assessment of Second-Generation Antibiofilm Compounds Active Against Salmonella.

Amy Sorge, Aliyah N Bennett, Sophia E Gregory, Allysa L Cole, Katherine J Woolard, Ansley M Nemeth, Andrew H Crow, Roberta J Melander, John S Gunn, Christian Melander

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amy SorgeDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Aliyah N BennettCenter for Microbe and Immunity Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Sophia E GregoryDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Allysa L ColeCenter for Microbe and Immunity Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Katherine J WoolardDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Ansley M NemethDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.ORCID https://orcid.org/0000-0001-7249-5688
Andrew H CrowDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Roberta J MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
John S GunnCenter for Microbe and Immunity Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Christian MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.ORCID https://orcid.org/0000-0001-8271-4696

Funding

Mechanisms of the Development and Maintenance of Salmonella Gallbladder CarriageR01AI116917 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GUNN, JOHN S, MELANDER, CHRISTIAN COREY · 2015 to 2025
$6.1M
Interdisciplinary Program in Microbe-Host BiologyT32AI165391 · NIAID · OHIO STATE UNIVERSITY · PI RAJENDAR K DEORA, Daniel J Wozniak · 2022 to 2026
$1.5M
CTSA Predoctoral T32 at the Ohio State UniversityT32TR004543 · NCATS · OHIO STATE UNIVERSITY · PI GINNY L BUMGARDNER · 2023 to 2026
$1.2M
NIAID NIH HHS R01 AI116917NIH HHS RO1AI116917NIH HHS T32AI165391NIH HHS T32TR004543
6 · The paper itself

Abstract

Typhoid fever is a life-threatening illness caused by Salmonella enterica subspecies enterica serovar Typhi. The organ most implicated in chronic carriage and host transmission is the gallbladder due to bacterial biofilm formation on gallstones. Biofilms facilitate chronic infection because bacteria in biofilms are less susceptible to antibiotic treatment and immune factors in comparison to their planktonic brethren. Previously, we reported compounds that disrupt biofilms of Salmonella enterica serovar Typhimurium, a serovar closely related to S. Typhi, both in vitro and in vivo. This work extends the development of Salmonella antibiofilm agents through the further exploration of the parent scaffold. Lead antibiofilm compounds were tested for human ether-a-go-go-related gene (hERG) channel inhibition, from which we report new lead compounds with improved antibiofilm activity and reduced hERG channel inhibition.

Indexed as

Anti-Bacterial AgentsBiofilmsERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsSalmonella typhiSalmonella typhimuriumDose-Response Relationship, DrugHumansMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsERG1 Potassium ChannelEther-A-Go-Go Potassium Channelsbiofilmbiologychronic infectionhERGmicrobiologyS almonellaS almonella entericaS almonella Typhiserotypetyphoid fever

Identifiers

PMID42437701
PMCPMC13357029

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.