Evidence map›Paper›PMID 42438228›Full record

ArticleDrug development research2026

Ameliorative Effects of a Naphthoquinone Derivative With β-Amyloid Aggregation Inhibitory Activity on Cognitive Impairment and Metabolite Analysis of the Blood and Brains of Mice.

Jong Min Oh, Won Kyeong Jeong, Hyun Ju Son, Seo Young Kim, Tae Woo Oh, Moongi Ji, Ji Woo Nam, Minyeong Baek, Jeong-Ho Park, Woong-Hee Shin and 4 more

Abstract read
In one paragraph

Article in Drug development research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jong Min OhDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea.
Won Kyeong JeongDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea.
Hyun Ju SonDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea.
Seo Young KimKorean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu, Republic of Korea.
Tae Woo OhKorean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu, Republic of Korea.ORCID https://orcid.org/0000-0001-7184-6503
Moongi JiDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea.
Ji Woo NamDepartment of Chemical & Biological Engineering, Hanbat National University, Daejeon, Republic of Korea.
Minyeong BaekDepartment of Biomedical Informatics, College of Medicine, Korea University, Seoul, Republic of Korea.
Jeong-Ho ParkDepartment of Chemical & Biological Engineering, Hanbat National University, Daejeon, Republic of Korea.
Woong-Hee ShinDepartment of Biomedical Informatics, College of Medicine, Korea University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-3462-0243
Hee Jung KimDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea.
Byeongchan ChoiDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea.
Man-Jeong PaikDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea.
Hoon KimDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea.

Funding

National Research Foundation of Korea (NRF) RS-2024-00347522
6 · The paper itself

Abstract

Accumulation of amyloid-β (Aβ) plaques is an important cause of Alzheimer's disease (AD) pathogenesis. In this study, we evaluated Aβ aggregation inhibitory activity of synthesized naphthoquinone derivatives as well as improvement in cognitive functions and metabolite profiling of brain tissues using scopolamine (SCO)-induced mice. Compound 888 (2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)naphthalene-1,4-dione, [TPN]) showed the highest Aβ aggregation inhibitory activity (IC

Indexed as

Amyloid beta-PeptidesCognitive DysfunctionNaphthoquinonesNeuroprotective AgentsAlzheimer DiseaseAnimalsBrainCognitive EnhancementHumansMadin Darby Canine Kidney CellsMaleMicePeptide FragmentsScopolamineAmyloid beta-PeptidesNaphthoquinonesNeuroprotective AgentsPeptide FragmentsScopolamine2‐(4‐(2,3,4‐trimethoxybenzyl)piperazin‐1‐yl)naphthalene‐1,4‐dioneAβ aggregation inhibitory activitymetabolite profilingmolecular dynamics simulationmouse behavioral testsWestern blotting

Identifiers

PMID42438228
PMCPMC13358321

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.