ArticleMicrobial biotechnology2026
Dual Silencing of Aminoglycoside Biosynthesis for the Discovery of Novel Antimicrobials in Streptomyces.
Yuncong Xu, Yali Du, Jiarong Yu, Yinghui Zhao, Zhenlin Li, Jufen Wang, Yijun Chen, Deli Xiao, Xuri Wu
Abstract read
In one paragraphArticle in Microbial biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Yuncong XuDepartment of Microbiology and Synthetic Biology, College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China.
Yali DuDepartment of Microbiology and Synthetic Biology, College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China.
Jiarong YuDepartment of Microbiology and Synthetic Biology, College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China.
Yinghui ZhaoDepartment of Microbiology and Synthetic Biology, College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China.
Zhenlin LiDepartment of Pharmaceutical Analysis and Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu Province, People's Republic of China.
Jufen WangDepartment of Pharmacy, Jiangbei Campus of The First Affiliated Hospital of Army Medical University, Chongqing, People's Republic of China.
Yijun ChenDepartment of Microbiology and Synthetic Biology, College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China.
Xuri WuDepartment of Microbiology and Synthetic Biology, College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China.ORCID https://orcid.org/0000-0002-0933-5902 Funding
Anti-Infective Drug Research and Development Project at China Pharmaceutical University YZZKY012Key Research and Development Project of Guangdong Province 2022B1111070004National College Students Innovation and Entrepreneurship Training Program 202510316037ZNational Natural Science Foundation of China 81973214
6 · The paper itselfAbstract
Streptomyces species are prolific sources of antimicrobials, yet their vast biosynthetic capacity remains underexploited due to the rediscovery of common antibiotics (e.g., ~1% for streptomycin and ~10% for streptothricin). To address this challenge, we developed a dual-layer biosynthetic blockade system, designated CI-ARS
Indexed as
AminoglycosidesAnti-Bacterial AgentsGene SilencingStreptomycesAcinetobacter baumanniiBiosynthetic PathwaysDrug DiscoveryMicrobial Sensitivity TestsMultigene FamilyAminoglycosidesAnti-Bacterial Agents
Identifiers
PMID42438233
PMCPMC13358218
What Socratic holds
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