ArticleImmunity, inflammation and disease2026
TRPM2 Deficiency Attenuates Allergic Rhinitis-Like Inflammation With Altered Ca
Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- TRPM2 Deficiency Attenuates Allergic Rhinitis-Like Inflammation With Altered CaImmunity, inflammation and disease · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundAllergic rhinitis (AR) is a prevalent chronic inflammatory condition characterized by nasal itching, sneezing, and congestion, significantly impairing patients' quality of life. Despite the availability of various therapeutic options, treatment efficacy remains suboptimal for certain patients, and long-term use may be accompanied by adverse effects.
objectiveThis study examined the role of transient receptor potential melastatin 2 (TRPM2) in AR-like inflammation, focusing on its associations with T cell functionality, Th2 inflammatory responses, Treg/Th17 balance, and upstream Ca
methodsUsing TRPM2 knockout and WT mice within an ovalbumin-induced AR model, this research integrated behavioral assessments, histopathological analyses, immunological assays, qPCR, and Western blotting to evaluate the implications of TRPM2 deficiency for clinical symptoms, inflammatory responses, immune cell differentiation, and related signaling pathways.
resultsTRPM2 knockout mice exhibited reduced clinical symptoms and nasal inflammation, lower serum OVA-specific IgE levels, and reduced expression of key inflammatory cytokines, including IL-4, IL-5, and IL-33. Furthermore, TRPM2 deficiency was associated with expansion of Treg cells, reduced Ca
conclusionThese findings suggest that TRPM2 participates in OVA-induced AR-like inflammation through immune and Ca
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.