Evidence map›Paper›PMID 42438359›Full record

ArticleGlia2026

Genetic Deletion of Adenosine A

Cátia R Lopes, Samira G Ferreira, Rodrigo A Cunha, Paula Agostinho

Abstract read
In one paragraph

Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cátia R LopesCiBB-Centre for Innovative Biomedicine and Biotechnology, Coimbra, Portugal.
Samira G FerreiraCiBB-Centre for Innovative Biomedicine and Biotechnology, Coimbra, Portugal.
Rodrigo A CunhaCiBB-Centre for Innovative Biomedicine and Biotechnology, Coimbra, Portugal.
Paula AgostinhoCiBB-Centre for Innovative Biomedicine and Biotechnology, Coimbra, Portugal.ORCID 0000-0001-5523-4945

Funding

European Union's Horizon 2020 857524Fundação para a Ciência e a Tecnologia 2021.06954.BDFundação para a Ciência e a Tecnologia COMPETE2030-FEDER-0067630Fundação para a Ciência e a Tecnologia UIDB/04539/2020Programa Operacional Regional do Centro Centro 2020 (CENTRO-01-0246-FEDER-000010)
6 · The paper itself

Abstract

Although brain disorders are the major burden of disease in Western countries and their incidence increases sharply with aging, the biological basis of brain aging is still poorly explored. Glial cells, namely microglia and astrocytes, maintain brain homeostasis and mount neuroinflammation that can contribute to age-related deterioration of brain functions. The purinergic system, particularly adenosine A

Indexed as

AgingHippocampusInflammasomesNeurogliaPrefrontal CortexReceptor, Adenosine A2AAnimalsAstrocytesCaspase 1MaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, Purinergic P2X7Adora2a protein, mouseCaspase 1InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinReceptor, Adenosine A2AReceptors, Purinergic P2X7A2A receptorsagingastrocytesbrainmicrogliaNRLP3 inflammasomeP2X7 receptors

Identifiers

PMID42438359
PMCPMC13358461

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.