ArticleNeural plasticity2026
Amantadine Reshapes Brain Oscillatory Dynamics in Pediatric Disorders of Consciousness.
Article in Neural plasticity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Amantadine Reshapes Brain Oscillatory Dynamics in Pediatric Disorders of Consciousness.Neural plasticity · 2026Article
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDisorders of consciousness (DoC) in children following severe brain injury remain a major clinical challenge, and pharmacological interventions with objective neurophysiological evidence are limited. Amantadine has shown potential benefits in adult DoC, but its neural effects in pediatric populations remain poorly understood. This study investigated whether amantadine treatment is associated with changes in resting-state electroencephalography (EEG) oscillatory dynamics in children with DoC.
methodsThirty participants were enrolled, including 15 children with DoC and 15 age- and sex-matched typically developing (TD) controls. The DoC group received oral amantadine for 1 month at weight-adjusted doses. Resting-state EEG was recorded at baseline and after treatment. Relative EEG amplitude (RelAmp) was calculated for five frequency bands (delta, theta, alpha, beta, and gamma), and two spectral ratios-the alpha-theta ratio (ATR) and the slow-fast frequency ratio (SFR)-were derived to characterize the balance between slow and fast oscillatory activity. Behavioral responsiveness was assessed using the Coma Recovery Scale-Revised (CRS-R).
resultsAt baseline, children with DoC showed significantly lower ATR, SFR, alpha amplitude, and gamma amplitude than TD controls, indicating a shift toward slower cortical oscillatory activity. ATR, SFR, and alpha amplitude were positively correlated with CRS-R scores, suggesting that faster oscillatory dynamics were associated with better behavioral responsiveness. Following amantadine treatment, ATR, alpha amplitude, and gamma amplitude increased significantly within the DoC group, reflecting a shift toward faster cortical oscillatory activity. Notably, these EEG changes preceded overt behavioral improvement: CRS-R scores did not change significantly immediately after treatment but improved significantly at the 3-month follow-up. This temporal dissociation suggests that neurophysiological recovery may emerge earlier than overt behavioral responsiveness and may be relevant to covert recovery processes in pediatric DoC.
conclusionAmantadine treatment was associated with selective modulation of cortical oscillatory dynamics in children with DoC. EEG spectral measures may provide objective biomarkers for detecting early neural recovery and monitoring longitudinal brain changes in pediatric DoC.
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