ArticleJournal of molecular and cellular cardiology plus2026
Coronary artery disease in smokers with low traditional risk burden: An exploratory analysis of potential genetic susceptibility.
Article in Journal of molecular and cellular cardiology plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/objectives: Coronary arterial disease (CAD) poses a significant public health challenge, with tobacco as the most predominant modifiable risk factor in young individuals. Despite a strong correlation between tobacco use and CAD, many smokers remain CAD-free. This fact raises questions about the complex interplay between environmental and genetic factors that contribute to CAD. Objective: Identify genetic polymorphisms that may be responsible for CAD in smokers without the main cardiovascular risk factors. Methods: A small retrospective case-control association study included current smokers aged 35-50 with low-density lipoprotein (LDL) levels <100 mg/dL who were non-diabetic and non-hypertensive. A total of 134 individuals (83% male; mean age of 48.9 ± 8.4 years) were selected from the GENEMACOR population: 97 CAD patients defined as having at least 70% stenosis in one major coronary artery, and 37 controls without CAD. Nine genetic variants from 8 genes previously associated with CAD but not with traditional risk factors (TRFs) were genotyped using TaqMan real-time PCR: Results: The intronic Conclusions: Our findings show that the
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