Advanced hydrogel-based drug delivery systems for psoriasis management: From material design to multi-target therapies.

Huijuan Liang, Huina Cao, Shulin Pu, Runqi Xu, YaQi Xu, Chengxiao Wang

Abstract readReview

In one paragraph

Review in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huijuan LiangSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.

Huina CaoSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.

Shulin PuSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.

Runqi XuSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.

YaQi XuSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.

Chengxiao WangSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory skin disorder driven by the interplay of genetic, immunological, and environmental factors. Hydrogels, featuring excellent biocompatibility and tunable structures, have emerged as pivotal platforms for topical psoriasis management. Although existing studies have explored hydrogel drug delivery and sustained release, they often remain confined to single-target interventions or basic formulations. This review updates recent advances by elucidating intervention mechanisms from the pathological microenvironment. We highlight synergistic strategies using smart hydrogels and nanogels, with emphasis on their core strengths in sustained/controlled release, enhanced penetration, and dosage form design. Finally, future perspectives and targeted strategies are proposed to address critical bottlenecks in clinical translation, including manufacturing standards and long-term safety. This work aims to provide theoretical guidance for developing next-generation hydrogel formulations with high efficacy and low toxicity.

Indexed as

HydrogelsMulti-target therapiesPsoriasisStimuli-responsiveTransdermal drug delivery

Identifiers

PMID42438664

DOI10.1016/j.ijpx.2026.100599

PMCPMC13356674

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.