Evidence map›Paper›PMID 42439047›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026

The social environment and cognitive aging over the life course: laying out critical concepts and research gaps.

Margaret T Hicken, Reed DeAngelis, David Rigby, Lindsey Burnside, Sara Adar, Sarah Burgard, Brigette A Davis, Rachel Donnelly, Jessica M Finlay, Anjum Hajat and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Margaret T HickenInstitute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Reed DeAngelisInstitute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
David RigbyInstitute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Lindsey BurnsideInstitute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Sara AdarDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Sarah BurgardInstitute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Brigette A DavisSchool of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA.
Rachel DonnellyDepartment of Sociology, Vanderbilt University, Nashville, Tennessee, USA.
Jessica M FinlayDepartment of Geography, University of Colorado Boulder, Boulder, Colorado, USA.
Anjum HajatDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Jinkook LeeDepartment of Economics, University of Southern California, Los Angeles, California, USA.
Brea L PerryDepartment of Sociology, Indiana University Bloomington, Bloomington, Indiana, USA.
Lorna E ThorpeDepartment of Population Health, NYU Grossman School of Medicine, New York, New York, USA.
Debra UmbersonDepartment of Sociology, University of Texas at Austin, Austin, Texas, USA.

Funding

Program Development and Pilot CoreP30AG066614 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI KAREN L FINGERMAN · 2020 to 2026
$5.2M
Racial inequalities in health throughout adulthood: The cumulative impact of neighborhood chemical and non-chemical stressors on epigenomic pathwaysR01MD013299 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HICKEN, MARGARET TAKAKO · 2018 to 2022
$3.7M
Epigenetic mechanisms underlying the direct and moderating effects of social connectedness on complex diseases in agingR01AG076032 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI Brea Louise Perry · 2022 to 2026
$2.9M
ACL-LIFE Life History Interview and ValidationR01AG065319 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURGARD, SARAH A. · 2020 to 2024
$2.7M
The role of precarious work in the production of health disparities in older agesR01AG060011 · NIA · UNIVERSITY OF WASHINGTON · PI HAJAT, ANJUM · 2018 to 2021
$1.7M
NIA NIH HHS P30AG066614NIA NIH HHS R01AG060011NIA NIH HHS R01AG065319NIA NIH HHS R01AG076032NIA NIH HHS R37AG57739NIA NIH HHS U25AG088894NIMHD NIH HHS R01MD013299
6 · The paper itself

Abstract

The social environment refers to our interpersonal relations, workplaces, and neighborhoods, towns, or cities in which we live. A growing literature indicates that social environments are related to cognitive aging and risk of Alzheimer's disease and related dementias (AD/ADRD). Still, relatively little is known about how social-environmental exposures affect cognitive function over the life course and into older ages. Addressing this limitation, our paper outlines key features of the social environment and recommends priority areas of research on the social environment and cognitive aging. We divide our discussion into three subdomains: social connections, residential context, and work context. We then identify important gaps in the conceptual and empirical literature before outlining avenues for future research to strengthen our understanding of how social-environmental exposures over the life course link with cognitive function and AD/ADRD risk in late life.

Indexed as

AgingCognitive AgingSocial EnvironmentAlzheimer DiseaseHumansResidence Characteristicsneighborhoodresidential contextsocial connectionssocial environmentwork context

Identifiers

PMID42439047
PMCPMC13358813

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.