Observational studyJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
Association of Systemic Hemodynamics and Endothelial Dysfunction With Clinical Phenotypes in Sensorineural Hearing Loss With Vertigo: A Cross-Sectional Analysis.
Observational study in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
importanceSensorineural hearing loss (SNHL) accompanied by vertigo is a condition with clinical heterogeneity. Understanding vascular underpinnings is crucial for management.
objectiveTo investigate the association of systemic hemodynamics and endothelial dysfunction with the distinct clinical manifestations of SNHL with vertigo.
designA descriptive, hospital-based cross-sectional study.
settingDepartment of Otolaryngology Head and Neck Surgery at a tertiary academic hospital.
participantsOne hundred forty-two consecutive patients with SNHL and vertigo (disease duration ≤30 days) enrolled between January 2023 and October 2025.
interventionObservational study; no intervention was performed.
main outcome measuresPure-tone audiometry (PTA) including high-frequency thresholds (6-8 kHz), Dizziness Handicap Inventory (DHI), Tinnitus Evaluation Questionnaire, transcranial Doppler for mean flow velocity (Vm), and serum endothelin-1 (ET-1)/nitric oxide (NO). Linear regression analyzed associations.
resultsLinear regression showed PTA was significantly predicted by higher ET-1 (
conclusionsSystemic hemodynamic compromise and endothelial dysfunction differentially associate with hearing and vestibular phenotypes. Cochlear symptoms may be driven by endothelial-mediated vasoconstriction, while vestibular symptoms are more sensitive to macrovascular flow reduction. RELEVANCE: Vascular profiling could inform targeted therapeutic strategies.
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