ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
HMGCR-Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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20 authors.
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Abstract
Dysregulated cholesterol metabolism has been implicated in several aging-associated disorders, including osteoarthritis (OA). 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the key enzyme in cholesterol biosynthesis, but the role of HMGCR in OA and the underlying mechanism remain unclear. In this study, we found that HMGCR
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