Evidence mapPaperPMID 42439400Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

HMGCR-Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence.

Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang and 10 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xiaoqi ZhangDepartment of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Siru ZhouWar Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical Center, Daping Hospital, Army Medical University, Chongqing, China.
Xi LiuDepartment of Otorhinolaryngology and Maxillofacial Surgery, The 988th Hospital of the Joint Logistics Support Force, Zhengzhou, China.
Wei XiangDepartment of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Xiuqin PengMetabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Yu TianMetabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Song LiMetabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Hailin WangMetabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Bo LiaoDepartment of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shunzheng FangDepartment of Emergency Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Runze JinDepartment of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Jinhui WuDepartment of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Chuanqing BaiDepartment of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Wei ZhangDepartment of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Bo HuangDepartment of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Bingfei LiDepartment of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Lifeng ChenDepartment of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Lin ChenMetabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.ORCID https://orcid.org/0000-0001-7764-9412
Bin ZhangMetabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.ORCID https://orcid.org/0000-0002-7097-2011
Zhenhong NiDepartment of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.ORCID https://orcid.org/0000-0002-7464-4074

Funding

Chongqing Medical Scientific Research Project (Joint project of Chongqing Municipal Health Commission and Chongqing Science and Technology Commission) 2024DBXM008National Natural Science Foundation of China 82394444 82572843 82372495Natural Science Foundation of Chongqing CSTB2024NSCQ-JQX0019
6 · The paper itself

Abstract

Dysregulated cholesterol metabolism has been implicated in several aging-associated disorders, including osteoarthritis (OA). 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the key enzyme in cholesterol biosynthesis, but the role of HMGCR in OA and the underlying mechanism remain unclear. In this study, we found that HMGCR

Indexed as

cellular senescenceHMGCRosteoarthritissynovial fibroblast

Identifiers

PMID42439400
PMCPMC13360124

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.