Evidence map›Paper›PMID 42439550›Full record

ArticleMicrobiology spectrum2026

iPSC-based macrophage models reveal interferon-dependent control of RSV permissiveness and syncytia formation.

Ayse Agac, Debora Queiros, Eirini Nikolouli, Marie-Christin Knittler, Ariane H H Nguyen, Theresa Nägler, Martin Ludlow, Albert D M E Osterhaus, Gesine Hansen, Nico Lachmann and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ayse AgacResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.
Debora QueirosDepartment for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School (MHH), Hannover, Germany.
Eirini NikolouliDepartment for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School (MHH), Hannover, Germany.
Marie-Christin KnittlerResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.
Ariane H H NguyenDepartment for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School (MHH), Hannover, Germany.
Theresa NäglerDepartment for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School (MHH), Hannover, Germany.
Martin LudlowResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.ORCID 0000-0002-0061-1106
Albert D M E OsterhausResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.
Gesine HansenDepartment for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School (MHH), Hannover, Germany.
Nico LachmannDepartment for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School (MHH), Hannover, Germany.
Guus F RimmelzwaanResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.
Robert MeinekeResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.ORCID 0000-0003-4191-8021

Funding

Deutsche Forschungsgemeinschaft 390874280/EXC 2155, LA 3680/9-1, LA 3680/10-1Deutsche Forschungsgemeinschaft 398066876/GRK 2485/2REBIRTH HANNOVER Forschungszentrum für translationale regenerative Medizin (REBIRTH) ZN3340
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a leading cause of severe respiratory illness worldwide and affects mainly infants, immunocompromised individuals, and older adults. Understanding how immune cells contribute to RSV pathogenesis is crucial for developing interventions. However, the lack of model systems that accurately mimic

Indexed as

Giant CellsInduced Pluripotent Stem CellsInterferonsMacrophagesRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsHumansImmunity, InnateSignal TransductionVirus ReplicationInterferonsinnate immunityinterferonsiPSCmacrophagesrespiratory syncytial virusvirus-host interactions

Identifiers

PMID42439550
PMCPMC13435755

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.