ArticleCells2026
CRISPRi-Mediated Epigenetic Suppression of TERT Reduces Cell Growth in Non-Small-Cell Lung Cancer Cells.
Seong-Ho Park, Juyoung Hong, Woochang Hwang, Minjeong Kim, Hyeon Jong Yu, Taegeun Bae, Hyomin K Lee, Ji Yeoun Lee, Young Chan Lee, Chul-Kee Park and 1 more
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Seong-Ho ParkDepartment of Life Science, College of Natural Sciences, Hanyang University, Seongdong-gu, Seoul 04763, Republic of Korea.ORCID 0009-0009-9717-371X Juyoung HongDepartment of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Republic of Korea.ORCID 0000-0002-1989-7239 Woochang HwangHanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul 04763, Republic of Korea.
Minjeong KimDepartment of Medicine (AgeTech-Service Convergence Major), College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-0524-9281 Hyeon Jong YuDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Taegeun BaeHanyang Biomedical Research Institute, Hanyang University, Seoul 04763, Republic of Korea.
Hyomin K LeeHanyang Biomedical Research Institute, Hanyang University, Seoul 04763, Republic of Korea.
Ji Yeoun LeeDepartment of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Young Chan LeeDepartment of Medicine (AgeTech-Service Convergence Major), College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Chul-Kee ParkDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Junho K HurDepartment of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Republic of Korea.
Funding
Ministry of Science and ICT RS-2021-NR056589; RS-2023-00261114; RS-2025-02218918National Research Foundation of Korea RS-2023-00260529, RS-2026-25493418the Korea US Collaborative Research Fund RS-2025-16063805the Ministry of Education 2023R1A6C101A009
6 · The paper itselfAbstract
TERT, the catalytic subunit of telomerase, is aberrantly activated in most cancers and represents an attractive therapeutic target. However, conventional
Indexed as
Carcinoma, Non-Small-Cell LungCRISPR-Cas SystemsEpigenesis, GeneticLung NeoplasmsTelomeraseCell Line, TumorCell ProliferationCell SurvivalEpigenome EditingGene Expression Regulation, NeoplasticHumansTelomeraseTERT protein, humancancer cellsCRISPR interferencedCas9-KRABgene regulationtelomeraseTERTtranscriptional repression
Identifiers
PMID42439627
PMCPMC13359582
What Socratic holds
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LicenceCC BY
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