Evidence mapPaperPMID 42439648Full record

ReviewCells2026

Gut Microbiota Dysbiosis Is a Key Driver of Inflammaging in Chronic Kidney Disease.

Emanuele Parodi, Luigi Mario Castello, Paolo Bottino, Franca Gotta, Marialuisa Novi, Marco Orsello, Andrea Rocchetti, Stefania Prenna, Vincenzo Cantaluppi, Marco Quaglia

Abstract readReview
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emanuele ParodiNephrology and Dialysis Unit, SS. Antonio e Biagio e Cesare Arrigo University Hospital, 15121 Alessandria, Italy.ORCID 0000-0002-7365-7287
Luigi Mario CastelloInternal Medicine Unit, SS. Antonio e Biagio e Cesare Arrigo University Hospital, 15121 Alessandria, Italy.
Paolo BottinoMicrobiology Unit, SS. Antonio e Biagio e Cesare Arrigo University Hospital, 15121 Alessandria, Italy.ORCID 0000-0002-6337-5729
Franca GottaMicrobiology Unit, SS. Antonio e Biagio e Cesare Arrigo University Hospital, 15121 Alessandria, Italy.ORCID 0009-0006-2200-2674
Marialuisa NoviGastroenterology Unit, SS. Antonio e Biagio e Cesare Arrigo University Hospital, 15121 Alessandria, Italy.
Marco OrselloGastroenterology Unit, SS. Antonio e Biagio e Cesare Arrigo University Hospital, 15121 Alessandria, Italy.
Andrea RocchettiMicrobiology Unit, SS. Antonio e Biagio e Cesare Arrigo University Hospital, 15121 Alessandria, Italy.ORCID 0000-0002-6259-5295
Stefania PrennaDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Vincenzo CantaluppiDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0002-4120-3555
Marco QuagliaNephrology and Dialysis Unit, SS. Antonio e Biagio e Cesare Arrigo University Hospital, 15121 Alessandria, Italy.ORCID 0000-0001-9423-9255

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of gut microbiota and intestinal dysbiosis in promoting inflammaging in chronic kidney disease (CKD) has been the focus of intense research over the last years. Some alterations at the phyla level, such as abundance of

Indexed as

DysbiosisGastrointestinal MicrobiomeInflammationRenal Insufficiency, ChronicAnimalsFecal Microbiota TransplantationHumanschronic inflammationchronic kidney diseasedysbiosisend-stage kidney diseasefrailtygut microbiotainflammaging

Identifiers

PMID42439648
PMCPMC13359812

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.