Evidence map›Paper›PMID 42439672›Full record

ArticleCells2026

Increased Ca

Ruhul Amin, Zhanné Hopkinson, Louisa Wiede, Kazi T Haq, Penelope A Boyden, Henk E D J Ter Keurs, Bruno D Stuyvers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruhul AminDivision of BioMedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.ORCID 0000-0003-3566-4205
Zhanné HopkinsonDivision of BioMedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.ORCID 0009-0009-9779-468X
Louisa WiedeDivision of BioMedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.ORCID 0009-0009-2159-9693
Kazi T HaqChildren's National Hospital, Washington, DC 20010, USA.
Penelope A BoydenDepartment of Pharmacology, Centre for Molecular Therapeutics, Columbia University, New York, NY 10032, USA.
Henk E D J Ter KeursLibin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB T2N 1N4, Canada.
Bruno D StuyversDivision of BioMedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.ORCID 0000-0001-7744-3748

Funding

Ion Channel Function in Arrhythmogenic Cardiac CellsR01HL066140 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BOYDEN, PENELOPE ALTMAN · 2001 to 2010
$3.7M
CIHR 162181CIHR 81150National Heart Lung and Blood Institute HL-66140)NHLBI NIH HHS R01 HL066140
6 · The paper itself

Abstract

During acute coronary occlusion, ischemia is a major determinant of the cell response to subsequent reperfusion and is the major precursor of the typical "ischemia-reperfusion injury" (IRI). Therefore, elucidating the full IRI process primarily relies on a good understanding of ischemia-induced alterations. Ischemic arrhythmias frequently arise during the acute phase of a myocardial infarction (MI) and originate in the terminal arborisations of the cardiac conduction system. These ventricular arrhythmias are triggered by abnormal Ca

Indexed as

CalciumEndoplasmic ReticulumMyocardial InfarctionPurkinje CellsSarcoplasmic ReticulumAnimalsDogsSarcoplasmic Reticulum Calcium-Transporting ATPasesCalciumSarcoplasmic Reticulum Calcium-Transporting ATPasesCa2+ arrhythmogenicitymyocardial infarctionPurkinje cellPurkinje-mediated arrhythmiaSERCASR-Ca2+ uptake

Identifiers

PMID42439672
PMCPMC13359873

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.