MAFA: A Master Regulator of β-Cell Maturation and Function.

Lizabeth Johnson, Mallory A Maurer, Jeeyeon Cha

Abstract readReview

In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lizabeth JohnsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0001-7049-6986

Mallory A MaurerDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Jeeyeon ChaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.

Funding

Burroughs Wellcome Fund Career Award for Medical ScientistsDoris Duke Charitable Foundation Physician Scientist FellowshipNIH HHS 5K08DK132507-04NIH HHS 5T32DK007563-38

6 · The paper itself

Abstract

Dynamic insulin secretion and glucose homeostasis are dependent on the appropriate maturation and function of pancreatic β-cells. The islet-enriched musculoaponeurotic fibrosarcoma oncogene family A (MAFA) transcription factor acts as a master regulator of β-cell identity and function, coordinating gene expression networks required for glucose-stimulated insulin secretion. Dysregulation of MAFA contributes to β-cell dysfunction, as reduced expression is detected early in the pathogenesis of Type 1 Diabetes and Type 2 Diabetes, while long-lived variants can drive monogenic forms of diabetes. In this review, we summarize the current understanding of MAFA on β-cell maturation and function in both the mouse and human. This includes structural features of the MAFA protein, regulation of

Indexed as

Insulin-Secreting CellsMaf Transcription Factors, LargeAnimalsCell DifferentiationGlucoseHumansInsulinProtein Processing, Post-TranslationalGlucoseInsulinMAFA protein, humanMaf Transcription Factors, Largebeta celldiabetesinsulinMAFApancreas

Identifiers

PMID42439674

DOI10.3390/cells15131199

PMCPMC13359618

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.