ArticleCells2026
Follistatin Mitigates Atherosclerosis Through Activation of Arginine Metabolism and Adipose Browning.
Golnaz Dirakvand, Shehla Pervin, Brian Villa, Christy Le, Kristine Yohanna, Victor Grijalva, Arnab Chattopadhyay, Satyesh K Sinha, Srinivasa T Reddy, Rajan Singh
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Golnaz DirakvandDepartment of Biology, California State University, Dominguez Hills, Los Angeles, CA 90747, USA.
Shehla PervinDepartment of Biology, California State University, Dominguez Hills, Los Angeles, CA 90747, USA.
Brian VillaDepartment of Biology, California State University, Dominguez Hills, Los Angeles, CA 90747, USA.ORCID 0009-0006-3942-5024 Christy LeDepartment of Biology, California State University, Dominguez Hills, Los Angeles, CA 90747, USA.
Kristine YohannaDepartment of Biology, California State University, Dominguez Hills, Los Angeles, CA 90747, USA.
Victor GrijalvaDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90747, USA.
Arnab ChattopadhyayDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90747, USA.
Satyesh K SinhaDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90747, USA.
Srinivasa T ReddyDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90747, USA.ORCID 0000-0003-2959-9531 Rajan SinghDivision of Endocrinology and Metabolism, College of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90747, USA.ORCID 0000-0002-6409-4910 Funding
Sustaining Faculty Development & Community EngagementS21MD000103 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI CARLISLE, DAVID M · 2001 to 2015
$73.9MWorkshop for Junior Biostatisticians in Health ResearchU54MD007598 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI Yong Wu · 2012 to 2026
$60.0MNovel Approaches for Improving Inflammation Resolution Following Chronic Exposure to Air PollutantsR01ES033660 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REDDY, SRINIVASA T. · 2022 to 2025
$1.8MFollistatin promotes browning and influences energy metabolismSC1AG049682 · NIA · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI SINGH, RAJAN · 2014 to 2017
$1.1MFollistatin regulation of energy and lipid metabolism during progression of atherosclerosisR16GM145591 · NIGMS · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI SINGH, RAJAN · 2022 to 2025
$580kElectronic cigarettes, oxidative stress and development of breast tumorR16GM149471 · NIGMS · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI SHEHLA PERVIN · 2023 to 2026
$574kCharles R. Drew University of Medicine and Science UHI NIMHD S21MD000103 and U54MD007598NIA NIH HHS SC1 AG049682NIEHS NIH HHS R01 ES033660NIGMS NIH HHS R16 GM145591NIGMS NIH HHS R16 GM149471NIMHD NIH HHS S21 MD000103NIMHD NIH HHS U54 MD007598
6 · The paper itselfAbstract
Follistatin (FST) binds to and neutralizes members of the transforming growth factor-beta (TGF-β) superfamily, thereby regulating diverse physiological processes, including regulation of skeletal muscle, adipose, and bone homeostasis. FST also promotes adipose browning and enhances energy metabolism, leading to improved plasma lipid profiles and metabolic health in mice. Given the emerging association between brown adipose tissue (BAT) activation and reduced atherosclerosis, we investigated the anti-atherogenic potential of FST. Transcriptomic and metabolomic analyses of the Hybrid Mouse Diversity Panel (HMDP) revealed that
Indexed as
Adipose Tissue, BrownArginineAtherosclerosisFollistatinAdipose Tissue, WhiteAnimalsArginaseDependovirusMaleMiceMice, Inbred C57BLReceptors, LDLUncoupling Protein 1ArginaseArginineFollistatinReceptors, LDLUncoupling Protein 1adeno-associated virusarginase 1fibroblast growth factor 21follistatinlow-density lipoproteinmouse embryonic fibroblastwhite adipose tissue
Identifiers
PMID42439678
PMCPMC13360072
What Socratic holds
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LicenceCC BY
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