Effects of Prolonged Normobaric Hypoxia and Norepinephrine on the Rat Heart-Can They Be Reversed by Normoxic Recovery?

Beate Rassler, Charly Bambor, Sarah Daunheimer, Coralie Raffort, Aida Salameh

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Beate RasslerCarl-Ludwig-Institute of Physiology, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0003-3526-2388

Charly BamborCarl-Ludwig-Institute of Physiology, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.

Sarah DaunheimerCarl-Ludwig-Institute of Physiology, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.

Coralie RaffortDepartment of Pediatric Cardiology, Heart Centre, Leipzig University, 04289 Leipzig, Germany.ORCID 0009-0007-5915-6623

Aida SalamehDepartment of Pediatric Cardiology, Heart Centre, Leipzig University, 04289 Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies on rats showed a deterioration of left ventricular (LV) function and myocardial injury characterized by oxidative/nitrosative stress, PARylation, and apoptosis in the heart after three days of hypoxia. In the present study on rats, we investigated whether a three-day recovery period in normoxia can reverse myocardial injury and dysfunction. Further, we studied the effects of norepinephrine (NE) administration as a model of strong sympathetic activation on hypoxia-induced LV dysfunction and myocardial damage, as well as their reversibility. Three days of normobaric hypoxia (10% O

Indexed as

HeartHypoxiaNorepinephrineAnimalsApoptosisMaleMyocardiumNitrosative StressOxidative StressPoly Adenosine Diphosphate RiboseRatsRats, WistarTyrosineVentricular Dysfunction, LeftVentricular Function, Left3-nitrotyrosineNorepinephrinePoly Adenosine Diphosphate RiboseTyrosineapoptosis-inducing factorcardiac functionhypoxia/reoxygenationleft and right ventricular catheterizationnitrotyrosinenorepinephrineoxidative/nitrosative stressparthanatosPARylation

Identifiers

PMID42439682

DOI10.3390/cells15131207

PMCPMC13360307

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.