Sex-Dependent Vascular Responses to Atorvastatin Across Multiple Arterial Beds in a Mouse Model of Marfan Syndrome.

Patrick Hunt, Kimberly Huynh, Brikena Gusek, Anna Stimpson, Roshanak Rahimian, Mitra Esfandiarei

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Patrick HuntCollege of Osteopathic Medicine, Midwestern University, Glendale, AZ 85308, USA.

Kimberly HuynhCollege of Osteopathic Medicine, Midwestern University, Glendale, AZ 85308, USA.ORCID 0009-0000-7838-0988

Brikena GusekCollege of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.

Anna StimpsonCollege of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.

Roshanak RahimianThomas J. Long School of Pharmacy, University of the Pacific, Stockton, CA 95211, USA.ORCID 0000-0001-9803-0619

Mitra EsfandiareiCollege of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.ORCID 0000-0003-3218-7781

Funding

NIH HHS 1R15HL145646-19

6 · The paper itself

Abstract

Marfan syndrome (MFS) is characterized by progressive aortic aneurysm formation resulting from mutations in the fibrillin-1 (Fbn1) gene. Although the thoracic aorta is the primary site of pathology, accumulating evidence indicates that vascular dysfunction in MFS extends beyond the aorta to involve multiple arterial beds. Statins have been shown to attenuate aneurysm progression in experimental models of MFS; however, their effects on systemic vascular remodeling and arterial stiffness outside the aorta remain poorly characterized. In this study, we investigated the impact of chronic atorvastatin therapy on vascular structure and hemodynamic function across multiple vascular beds in the

Indexed as

ArteriesAtorvastatinMarfan SyndromeSex CharacteristicsAnimalsDisease Models, AnimalFemaleFibrillin-1HemodynamicsMaleMiceMice, Inbred C57BLVascular StiffnessAtorvastatinFibrillin-1aortic aneurysmcarotid arterycerebral arteryfibrillin-1Marfan syndromesex differences

Identifiers

PMID42439699

DOI10.3390/cells15131225

PMCPMC13359514

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.