Evidence map›Paper›PMID 42439703›Full record

ArticleCells2026

Reducing PI4KIIIα Levels or Activity Limits Tau Seed Internalization and Assembly in Human Cortical Neurons.

Eleonora Clemente, Ramakrishnan Sivasubramanian, Susanne Kordes, Priyanka Bhatia, Ruth Hans, Stefanie Vogel, Matthias Baumann, Bert Klebl, Jared Sterneckert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eleonora ClementeCenter for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0009-0002-8490-5458
Ramakrishnan SivasubramanianCenter for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, Germany.
Susanne KordesLead Discovery Center GmbH, 44227 Dortmund, Germany.ORCID 0000-0002-0326-8809
Priyanka BhatiaCenter for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, Germany.
Ruth HansLight Microscopy Facility, Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0001-9125-3705
Stefanie VogelCenter for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, Germany.
Matthias BaumannLead Discovery Center GmbH, 44227 Dortmund, Germany.
Bert KleblLead Discovery Center GmbH, 44227 Dortmund, Germany.ORCID 0000-0001-5475-9053
Jared SterneckertCenter for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0002-7688-3124

Funding

Federal Ministry of Research, Technology and Space 01EK1606ATUD Dresden University of Technology core funding
6 · The paper itself

Abstract

Tau protein aggregation and spreading are central features of neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. Here, we investigated the role of phosphatidylinositol 4-kinase type IIIα (PI4KIIIα) in regulating tau propagation. We first used tau biosensor cells to demonstrate that both pharmacological inhibition and genetic reduction in PI4KIIIα effectively reduce the seeding of tau aggregation by extracellular seeds. To extend these findings to a more physiologically relevant system, we generated induced pluripotent stem (iPS) cell-derived cortical neurons carrying pathogenic

Indexed as

Cerebral CortexNeuronsPhosphotransferases (Alcohol Group Acceptor)tau ProteinsHumansInduced Pluripotent Stem CellsMinor Histocompatibility AntigensMinor Histocompatibility Antigensphosphatidylinositol phosphate 4-kinasePhosphotransferases (Alcohol Group Acceptor)tau Proteinsdisease modelinginduced pluripotent stem cellsiPS cellsPI4KAPI4KIIIαprion-like spreadingtautauopathy

Identifiers

PMID42439703
PMCPMC13359555

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.