Evidence map›Paper›PMID 42440038›Full record

ArticleNeurochemical research2026

BjPro-7a, A Proline-Rich Peptide from Bothrops jararaca Venom, Reverses MPP⁺-Induced Locomotor Deficits and Rescues Mitochondrial, Redox, and Synaptic Proteomic Pathways in a Zebrafish Model of Parkinsonism.

Adolfo Luis Almeida Maleski, Felipe Assumpção da Cunha E Silva, Bruno Fiorelini Pereira, Carlos Alberto-Silva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adolfo Luis Almeida MaleskiExperimental Morphophysiology Laboratory, Natural and Humanities Sciences Center (CCNH), Universidade Federal do ABC (UFABC), São Bernardo do Campo, 09606-070, SP, Brazil.ORCID http://orcid.org/0000-0003-4430-0905
Felipe Assumpção da Cunha E SilvaExperimental Morphophysiology Laboratory, Natural and Humanities Sciences Center (CCNH), Universidade Federal do ABC (UFABC), São Bernardo do Campo, 09606-070, SP, Brazil.ORCID http://orcid.org/0009-0008-3658-6505
Bruno Fiorelini PereiraExperimental Danio rerio Facility (BEDAR), Universidade Federal de São Paulo - campus Diadema, Diadema, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-0416-7281
Carlos Alberto-SilvaExperimental Morphophysiology Laboratory, Natural and Humanities Sciences Center (CCNH), Universidade Federal do ABC (UFABC), São Bernardo do Campo, 09606-070, SP, Brazil. carlos.asilva@ufabc.edu.br.ORCID http://orcid.org/0000-0003-4519-8930

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) and related Parkinsonian conditions involve progressive disruption of mitochondrial homeostasis, redox balance, synaptic function, and proteostasis. Available therapies remain predominantly symptomatic, motivating the search for multitarget compounds acting across stress-sensitive pathways. BjPro-7a (pEDGPIPP), a proline-rich oligopeptide from Bothrops jararaca venom, exerts cytoprotective effects under oxidative stress, but its activity in an in vivo Parkinsonian-like model is unknown. Here we investigated whether BjPro-7a attenuates the behavioral and proteomic disturbances induced by 1-methyl-4-phenylpyridinium (MPP

Indexed as

Crotalid VenomsLocomotionMitochondriaOligopeptidesParkinsonian DisordersSynapses1-Methyl-4-phenylpyridiniumAnimalsBothropsDisease Models, AnimalOxidation-ReductionProlineProteomicsZebrafish1-Methyl-4-phenylpyridiniumCrotalid VenomsOligopeptidesProlineBehavioral phenotypingLabel-free proteomicsMitochondrial homeostasisParkinsonismVenom-derived peptideZebrafish model

Identifiers

PMID42440038
PMCPMC13364832

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.