Trial reportActa diabetologica2026
Sustained and attenuated effects of transitioning from supervised to self-managed resistance training in older adults with type 2 diabetes and sarcopenia: a randomized controlled trial.
Trial report in Acta diabetologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07398495 (Effects of Multimodal Training on Muscle Function and Glucose Metabolism in Middle-Aged and Older Adults With Type 2 Diabetes Mellitus and Sarcopenia), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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Effects of Multimodal Training on Muscle Function and Glucose Metabolism in Middle-Aged and Older Adults With Type 2 Diabetes Mellitus and Sarcopenia
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis randomized controlled trial examined whether benefits achieved during supervised resistance training (SRT) were sustained after transitioning to self-managed home-based training in older adults with type 2 diabetes mellitus (T2DM) and sarcopenia.
methodsIn this single-center, parallel-group trial, adults aged ≥ 65 years with T2DM and sarcopenia were randomized 1:1 to a 24-week resistance-training intervention or control. The intervention comprised 12 weeks of SRT followed by 12 weeks of self-managed home-based training. Co-primary outcomes were skeletal muscle index (SMI), handgrip strength (HGS), five-times-sit-to-stand (5TSTS), and SARC-CalF score. Secondary outcomes were HbA
resultsSixty-two participants were randomized (median age, 72 years; 67.7% female). At 12 weeks, SRT significantly improved HGS, 5TSTS performance, and SARC-CalF score, whereas SMI showed no significant between-group difference. At 24 weeks, SMI showed a modest favorable change, but earlier improvements in HGS, 5TSTS performance, and SARC-CalF score were attenuated after transition to self-managed training. SF-12 scores showed supportive, favorable patterns through 24 weeks, whereas HbA
conclusionsIn older adults with T2DM and sarcopenia, transition from SRT to self-managed home-based training produced outcome-specific effects. Functional gains diminished after supervision ended, whereas SMI showed a modest, delayed, favorable change. These findings suggest that hybrid support models incorporating periodic supervision, remote monitoring, automated reminders, and feedback-guided exercise logs may be needed to sustain adherence, exercise quality, and functional capacity.
trial registrationRetrospectively registered at ClinicalTrials.gov (NCT07398495), February 23, 2026.
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