Evidence map›Paper›PMID 42440190›Full record

ArticleJournal of neuro-oncology2026

Motor mapping to enable resections of peri-rolandic diffuse gliomas.

James S Trippett, Antonio Dono, Syed S Shams, Jaiprakash Gurav, Christopher M Williams, Ankush Chandra, Yoshua Esquenazi, Nitin Tandon

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Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

James S TrippettVivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), 1133 John Freeman Blvd., JJL 420, Houston, TX, 77030, USA.
Antonio DonoVivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), 1133 John Freeman Blvd., JJL 420, Houston, TX, 77030, USA.
Syed S ShamsVivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), 1133 John Freeman Blvd., JJL 420, Houston, TX, 77030, USA.
Jaiprakash GuravVivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), 1133 John Freeman Blvd., JJL 420, Houston, TX, 77030, USA.
Christopher M WilliamsVivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), 1133 John Freeman Blvd., JJL 420, Houston, TX, 77030, USA.
Ankush ChandraVivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), 1133 John Freeman Blvd., JJL 420, Houston, TX, 77030, USA.
Yoshua EsquenaziVivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), 1133 John Freeman Blvd., JJL 420, Houston, TX, 77030, USA.
Nitin TandonVivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), 1133 John Freeman Blvd., JJL 420, Houston, TX, 77030, USA. Nitin.tandon@uth.tmc.edu.ORCID http://orcid.org/0000-0002-2752-2365

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraoperative motor mapping is essential for maximum safe resection of peri-Rolandic gliomas. While both awake and asleep techniques have demonstrated efficacy in preserving neurological function, comparative outcomes across WHO 2021 molecular tumor subtypes remain poorly defined. We compare outcomes between these mapping modalities in glioblastoma (GBM) and IDH-mutant gliomas.

methodsA 130-patient cohort undergoing peri-Rolandic glioma resection with intraoperative motor mapping at a single institution was analyzed. Patients were stratified by mapping modality (awake n = 54, asleep n = 76) and tumor subtype (WHO 2021). Within the asleep cohort, handheld probe (HHP-DCS, n = 61) and subdural electrode direct cortical stimulation (SDE-DCS, n = 12) were compared. The primary outcome was new or worsening neurological deficits at 3 months. Secondary outcomes included Karnofsky Performance Status (KPS), hospital length of stay, discharge disposition, and survival in GBM patients.

resultsThree-month deficit rates were comparable between awake and asleep mapping (5.6% vs. 5.3%, p = 1.000). In GBM patients, pre- and postoperative KPS were significantly lower in the asleep group (p < 0.001 and p = 0.002), though delta KPS and 3-month deficit rates did not differ. No deficits occurred in either group among IDH-mutant gliomas. Progression-free and overall survival were comparable between mapping modalities in GBM. HHP-DCS and SDE-DCS produced similar 3-month deficit rates (3.3% vs. 16.7%, p = 0.124).

conclusionAwake and asleep motor mapping were associated with comparable neurological outcomes across glioma subtypes, supporting asleep mapping as a reasonable alternative when awake craniotomy is not feasible, though these retrospective data do not establish statistical equivalence. HHP-DCS and SDE-DCS appear comparable in safety. Larger prospective studies are needed to confirm these findings.

Indexed as

Brain MappingBrain NeoplasmsGliomaNeurosurgical ProceduresAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesWakefulnessAsleep craniotomyAwake craniotomyGlioblastomaIntraoperative mappingMotor mappingPeri-rolandicSubdural strip electrode

Identifiers

PMID42440190
PMCPMC13364823

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.