Evidence map›Paper›PMID 42440232›Full record

ArticleMolecular and cellular biochemistry2026

Carvacrol induces apoptosis, modulates oxidative stress, and promotes G0/G1 cell cycle arrest in colorectal cancer cells.

Asmaa Abuaisha, Halil Ibrahim Arslan, Emir Nekay, Ramazan Aciroglu, Cuneyd Yavas, Nermin Akcali, Dima Dvaidar, Tugba Bayramoglu, Esra Nazligul, Tarik Mecit and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Asmaa AbuaishaDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Biruni University, 10. Yıl Cd. No:45, 34010, Zeytinburnu, Istanbul, Turkey. asmaa.m.abuaisha@gmail.com.ORCID https://orcid.org/0000-0003-2869-6620
Halil Ibrahim ArslanBiruni University Advanced Technology and Research Center B@MER, Biruni University, Istanbul, Turkey.ORCID http://orcid.org/0009-0001-4172-4748
Emir NekayBiruni University Advanced Technology and Research Center B@MER, Biruni University, Istanbul, Turkey.ORCID http://orcid.org/0009-0001-2389-0486
Ramazan AcirogluDepartment of General Surgery, Faculty of Medicine, Biruni University, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-2148-0173
Cuneyd YavasDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Biruni University, 10. Yıl Cd. No:45, 34010, Zeytinburnu, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-1597-5922
Nermin AkcaliDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Biruni University, 10. Yıl Cd. No:45, 34010, Zeytinburnu, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-6816-9687
Dima DvaidarDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Biruni University, 10. Yıl Cd. No:45, 34010, Zeytinburnu, Istanbul, Turkey.ORCID http://orcid.org/0009-0006-3927-2080
Tugba BayramogluDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Biruni University, 10. Yıl Cd. No:45, 34010, Zeytinburnu, Istanbul, Turkey.ORCID http://orcid.org/0009-0006-7185-5753
Esra NazligulDepartment of Internal Medicine, Hematology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-7383-8619
Tarik MecitDepartment of Physiology, Faculty of Medicine, Biruni University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-3816-134X
Adem BayraktarDepartment of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-0463-6335
Selman EmirogluDepartment of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-9333-6926

Funding

Scientific Research Projects Coordination Unit of Biruni University BİRUNİ-BAP-12-2025-01-17
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a major therapeutic challenge due to toxicity, low tumor specificity, and multidrug resistance. Carvacrol, a natural monoterpenoid phenol with notable anticancer, anti-inflammatory, and antioxidant properties, has emerged as a promising compound. This study evaluated the anticancer efficacy and underlying molecular mechanisms of carvacrol in HT-29 CRC cells and CCD-18Co normal colon fibroblasts. Cell viability was assessed using CVDK-8, migration by wound healing assay, and apoptosis, reactive oxygen species (ROS) levels, and cell cycle distribution by flow cytometry. Expression levels of PDHA1, SOX2, CASP3, POLB, ABCC1, and E2F4 were quantified by qPCR. Bioinformatic analyses were performed using GEPIA2 for overall survival (OS) and disease-free survival (DFS) evaluation and STRING for protein-protein interaction (PPI) network analysis. Carvacrol exhibited dose-dependent cytotoxicity in HT-29 cells (IC

Indexed as

ApoptosisCarvacrolCell cycleColorectal cancerOxidative stressProliferation

Identifiers

PMID42440232

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.