ReviewDevelopment (Cambridge, England)2026
Synthetic developmental engineering of human liver organogenesis.
Review in Development (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In embryos, intrinsic and extrinsic signals cooperatively shape cellular decisions to form tissues and organs. Developmental engineering seeks to harness insights into the molecular mechanisms governing embryonic development and leverage pluripotent stem cells to enable the synthetic reconstitution of organ-like multicellular systems in vitro, including organoids. These cellular systems can partially emulate the complexity of in vivo organs in terms of structure and function, facilitating disease modeling and regenerative medicine applications. Nonetheless, the field faces challenges, such as ensuring reproducibility and achieving adult-level maturation. In this Review, we discuss liver development in the human embryo and current models that are routinely used for generating liver organoids in vitro as well as their limitations. Next, we discuss how synthetic biology and computational analyses can be integrated to enhance organoids, particularly liver organoids, by promoting vascularization, establishing zonation, refining fate specification and enabling responsiveness to external cues. Together, these approaches pave the way for next-generation multicellular human stem cell-derived systems.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.