Trial reportFrontiers in pharmacology2026
Epidural analgesia supplemented with lidocaine reduces maternal fever during labor: a randomized controlled trial.
Trial report in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The co-administration of neuraxial drugs can enhance analgesic effects and reduce adverse events associated with epidural labor analgesia. This study aimed to explore the effects of epidural analgesia supplemented with lidocaine on maternal intrapartum fever. Methods: The control group received epidural analgesia with 0.1% ropivacaine and fentanyl 2 μg/mL, while Group L received epidural analgesia with 0.3% lidocaine, 0.1% ropivacaine, and fentanyl 2 μg/mL. Maternal temperature, pain intensity, fetal heart rate, and labor outcomes were recorded. Adverse events, if any, were also documented. Results: Initially, 400 women were enrolled in this study. Ultimately, 184 were assigned to the control group (n = 184), and 186 were assigned to Group L (n = 186). The incidence of intrapartum fever was lower in Group L than in the control group (3.8% vs. 9.2%; odds ratio = 0.384, 95% CI [0.155-0.950], Conclusion: Epidural analgesia supplemented with lidocaine reduced the incidence of intrapartum fever and accelerated the onset of analgesia without increasing maternal or neonatal complications. Clinical Trial Registration: https://www.chictr.org.cn/, Identifier, ChiCTR2300075546.
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