ArticleFrontiers in immunology2026
Distinct mucosa-associated microbiota signatures and dysbiosis in Peutz-Jeghers syndrome polyps versus paired normal mucosa.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Peutz-Jeghers syndrome (PJS) is an Aim: To investigate the mucosal microbial signatures, dysbiosis characteristics, and potential biomarkers in PJS polyps versus paired normal small intestinal mucosa. Methods: A paired-sample design was adopted, enrolling 44 genetically confirmed PJS patients. Mucosa-associated microbiota was profiled via 5R 16S rRNA gene sequencing. Statistical analyses included Wilcoxon rank-sum test, ANOSIM, Spearman's correlation, and random forest modeling. Results: Alpha diversity (Observed species, Chao1, Shannon) was markedly reduced in polyps (all P < 0.001), while Simpson index increased (P < 0.001). Beta diversity differed significantly between groups (ANOSIM, R = 0.0667, P = 0.002). Polyps were enriched in Conclusion: PJS polyps exhibit significant mucosal microbial dysbiosis, which may serve as potential biomarkers and therapeutic targets for PJS.
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