SynthesisFrontiers in medicine2026
The efficacy of temperature-guided preventive care in reducing diabetic foot ulcer incidence and prolonging ulcer-free survival: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Introduction: Recurrence of diabetic foot ulcers (DFU) is a major clinical challenge, often leading to amputation. Temperature-guided preventive care based on skin temperature monitoring has been proposed as an early warning tool that can trigger preventive actions before overt ulceration develops. We conducted a systematic review and meta-analysis to evaluate its efficacy in preventing DFU recurrence in high-risk individuals. Methods: We systematically searched PubMed, Embase, the Wiley Online Library, and Web of Science for randomized controlled trials comparing temperature-guided preventive care based on skin temperature monitoring with standard care. The primary outcome was time to first ulcer recurrence, with the hazard ratio (HR) as the effect measure. The secondary outcome was overall recurrence incidence, measured by the risk ratio (RR). Results: Six randomized controlled trials involving a total of 917 participants were included. The meta-analysis demonstrated a significant protective effect for temperature-guided preventive care. The intervention group had a significantly lower hazard of ulcer recurrence compared with the control group (HR 0.63; 95% CI: 0.49-0.82; Conclusion: Temperature-guided preventive care appears to be an effective, patient-driven intervention that may reduce the risk and incidence of DFU recurrence in high-risk individuals. These findings support the potential integration of this simple, proactive tool into standard preventive care protocols to mitigate the severe consequences of this complication.
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