ArticleFrontiers in pediatrics2026
MRI-derived IVIM-modelled diffusion-weighted imaging does not predict clinical outcomes in fontan-associated liver disease: to monitor or not to monitor the liver?
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Fontan-associated liver disease (FALD) encompasses the spectrum of hepatic alterations in patients after Fontan palliation. FALD can progress from congestive hepatopathy to fibrosis to cirrhosis with portal hypertension, and is associated with an increased risk of hepatocellular carcinoma (HCC). Current guidelines recommend intensive yearly folIow-up to assess FALD severity. However, the opted surveillance methods are unable to distinguish hepatic congestion from fibrosis or cirrhosis. Additionally, current literature provides limited evidence that FALD surveillance prevents adverse events. Intravoxel incoherent motion (IVIM) modelled diffusion-weighted imaging (DWI) allows for non-invasive differentiation between hepatic congestion and fibrosis, and has been suggested as a surveillance strategy in FALD. The objective of this study is to investigate the prognostic value of MRI-derived IVIM-modelled DWI in patients with a Fontan circulation. Methods: In a prospective study, 59 consecutive Fontan patients underwent hepatic MRI for IVIM-modelled DWI measurements. Apparent diffusion coefficient (ADC) and parameters of hepatic congestion-namely, the fast diffusion component (D Results: Mean cohort age was 19 ± 8 years, 51% female. Mean ADC was (0.82 ± 0.11) × 10 Conclusion: IVIM-modelled DWI addresses a key diagnostic challenge in FALD by enabling distinction between hepatic congestion and fibrosis. However, even after this distinction, we did not find a relationship between IVIM-modelled DWI and clinical outcomes. These findings, in combination with current literature data, which also fail to demonstrate a relation between other non-invasive FALD assessment tools and outcome, raise the question whether the recommended intensive FALD monitoring strategies are justified.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.