SynthesisFrontiers in immunology2026
Tiny messengers, big impact: unlocking the power of extracellular vesicles in neonatal health and disease. a systematic review.
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Extracellular vesicles (EVs) are cell-derived, membrane-bound particles that have gained increasing attention for their roles in pathophysiology, diagnostics, and targeted therapies. This review aimed at systematically collecting and critically synthesizing current evidence on EVs derived from neonatal biological fluids, focusing on their involvement in neonatal health and disease and their potential diagnostic and prognostic value. Methods: A systematic literature review was conducted in PubMed and Scopus databases between August and November 2025. The study protocol was registered in PROSPERO (CRD420251151417). Results: Following a PRISMA-compliant search strategy, 43 predominantly observational studies were included, encompassing term and preterm neonates with small-to-moderate sample sizes and heterogeneous clinical settings. EVs were isolated from multiple biological matrices, most frequently umbilical cord and peripheral blood, with sampling mainly performed at birth or during early postnatal life. Overall, the findings demonstrate the consistent presence and biological activity of EVs across diverse neonatal conditions, supporting their potential role as pathophysiological mediators and candidate biomarkers. Conclusions: Although EVs appear to actively participate in key neonatal processes, the available evidence remains limited and methodologically heterogenous. Larger, standardized studies are required to clarify their biological functions and clinical utility. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251151417, identifier CRD420251151417.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.