Evidence map›Paper›PMID 42440698›Full record

ArticleFrontiers in immunology2026

Ablating

Linwei Wu, Haolin Jiang, Jianling Gao, Xiaolan Ji, Yu Chen, Zhenghao Ma, Xinying Li, Jin Wang, Yachen Zang, Ji Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Linwei Wu *The First Affiliated Hospital of Soochow University and The Second Affiliated Hospital of Soochow University and The Fourth Affiliated Hospital of Soochow University and School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, China.
Haolin Jiang *The First Affiliated Hospital of Soochow University and The Second Affiliated Hospital of Soochow University and The Fourth Affiliated Hospital of Soochow University and School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, China.
Jianling Gao *Department of Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Xiaolan JiDepartment of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yu ChenThe First Affiliated Hospital of Soochow University and The Second Affiliated Hospital of Soochow University and The Fourth Affiliated Hospital of Soochow University and School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, China.
Zhenghao MaThe First Affiliated Hospital of Soochow University and The Second Affiliated Hospital of Soochow University and The Fourth Affiliated Hospital of Soochow University and School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, China.
Xinying LiThe First Affiliated Hospital of Soochow University and The Second Affiliated Hospital of Soochow University and The Fourth Affiliated Hospital of Soochow University and School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, China.
Jin WangDepartment of General Surgery, The Fourth Affiliated Hospital of Soochow University, (Suzhou Dushu Lake Hospital), Suzhou, China.
Yachen ZangDepartment of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Ji ZhangDepartment of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xin ZhaoThe First Affiliated Hospital of Soochow University and The Second Affiliated Hospital of Soochow University and The Fourth Affiliated Hospital of Soochow University and School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, China.
Xuefeng WangThe First Affiliated Hospital of Soochow University and The Second Affiliated Hospital of Soochow University and The Fourth Affiliated Hospital of Soochow University and School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Under chronic infections or in tumors, persistent antigen exposure drives CD8 Methods: In this study, we explore the role of special AT-rich sequence-binding protein 1 (SATB1) in the differentiation of Tex-int cells from their precursors. We observed downregulation of SATB1 during Tpex-to-Tex-int differentiation in tumors. Notably, the genetic ablation of Results: Ablating Discussion: Our results identify SATB1 as a pivotal regulator of exhausted CD8

Indexed as

CD8-Positive T-LymphocytesCell DifferentiationMatrix Attachment Region Binding ProteinsT-Lymphocyte SubsetsAnimalsLymphocytes, Tumor-InfiltratingMiceMice, Inbred C57BLMice, KnockoutT-Cell ExhaustionTumor MicroenvironmentMatrix Attachment Region Binding ProteinsSatb1 protein, mouseeffector-like Tex- int cellsSatb1stem-like Tpex cellsTex-int cellsTpex cellstumor immunitytumor-infiltrating CD8+ T cells

Identifiers

PMID42440698
PMCPMC13333729

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.