SynthesisFrontiers in nutrition2026
Effects of enteral immunonutrition on postoperative complications of colorectal cancer surgery: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Objective: Enteral immunonutrition is extensively administered to patients who have undergone colorectal cancer (CRC) surgery. However, its efficacy in reducing postoperative complications and the length of hospital stay (LOS) remains controversial. The aims of our meta-analysis were to investigate the effects of enteral immunonutrition on postoperative complications in patients undergoing CRC surgery. Methods: We searched the PubMed, Web of Science, and Wanfang databases from January 2000 to December 2025 and the reference lists of selected randomized controlled trials (RCT) The odds ratio (OR), weighted mean difference (WMD) and 95% confidence interval (CI) were used to assess the association between enteral immunonutrition and postoperative complications in patients undergoing CRC surgery. Results: Nine studies involving 1,198 patients with CRC were identified. Our results demonstrated that enteral immunonutrition could reduce the incidence of infectious complications 95% CI among postoperative CRC patients (OR: 0.48; 95% CI: 0.34-0.66; Conclusions: Enteral immunonutrition could reduce the incidence of infectious complications in patients undergoing CRC surgery. However, it did not reduce the incidence of postoperative anastomotic leakage or ileus and did not shorten LOS of patients who underwent CRC surgery. Research registration unique identifying number UIN: The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD420261288947. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261288947, identifier: CRD420261288947.
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