Unveiling acetamide coupled benzothiazole hydrazones as potential anti-proliferative agents: an experimental and computational approach.

Mahnoor Imtiaz, Leentje Persoons, Dirk Daelemans, Steven De Jonghe, Shahid Hameed

Abstract read

In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mahnoor ImtiazDepartment of Chemistry, Quaid-I-Azam University Islamabad 45320 Pakistan shameed@qau.edu.pk.

Leentje PersoonsKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Molecular Genetics and Therapeutics in Virology and Oncology Research Group Herestraat 49, Box 1048 3000 Leuven Belgium.ORCID https://orcid.org/0000-0002-7898-0868

Dirk DaelemansKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Molecular Genetics and Therapeutics in Virology and Oncology Research Group Herestraat 49, Box 1048 3000 Leuven Belgium.

Steven De JongheKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Molecular Genetics and Therapeutics in Virology and Oncology Research Group Herestraat 49, Box 1048 3000 Leuven Belgium.ORCID https://orcid.org/0000-0002-3872-6558

Shahid HameedDepartment of Chemistry, Quaid-I-Azam University Islamabad 45320 Pakistan shameed@qau.edu.pk.ORCID https://orcid.org/0000-0002-1195-1659

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of benzothiazole acetamide hydrazones (8a-p) was synthesized and evaluated for anti-proliferative activity against various human cancer cell lines, including a pancreatic ductal adenocarcinoma (CAPAN-1), a colorectal carcinoma (HCT-116), a leukemia (HL60), a glioblastoma (LN229), a T lymphoblast (Molt-4), a non-small cell lung cancer (NCI-H460), and a B lymphoblast (Z138) cell line. Among the tested derivatives, compounds 8l, 8n, and 8o emerged as lead compounds, exhibiting cytotoxicity across multiple cell lines. Notably, compound 8o demonstrated selective cytotoxicity towards Z138 and LN229 cell lines, with IC

Identifiers

PMID42440848

DOI10.1039/d6ra03835b

PMCPMC13334533

What Socratic holds

Textmetadata

LicenceCC BY-NC

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.