Evidence map›Paper›PMID 42440946›Full record

ReviewFrontiers in cell and developmental biology2026

Ammonia metabolic reprogramming in the tumor microenvironment: emergence of an immunosuppressive niche.

Zihao Ye, Hao Wu, Zhanhao Li, Ruizhe Ye, Yingliang Rao, Bin Liu, Baoshan Gao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zihao YeDepartment of Urology II, The First Hospital of Jilin University, Changchun, China.
Hao WuDepartment of Urology II, The First Hospital of Jilin University, Changchun, China.
Zhanhao LiDepartment of Urology II, The First Hospital of Jilin University, Changchun, China.
Ruizhe YeSchool of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yingliang RaoDepartment of Urology, China-Japan Hospital of Jilin University, Changchun, China.
Bin LiuDepartment of Urology II, The First Hospital of Jilin University, Changchun, China.
Baoshan GaoDepartment of Urology II, The First Hospital of Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic reprogramming within the tumor microenvironment plays a pivotal role in tumor proliferation, progression, and immune evasion. Cancer cells exhibit altered lipid, glucose, and amino acid metabolism to adapt to hostile conditions such as hypoxia and nutrient deprivation. Particularly, ammonia metabolism has emerged as a critical aspect of tumor metabolic reprogramming. Oncogene mutations, such as those in

Indexed as

ammonia metabolismcancermetabolic reprogramSLC (solute carrier family)TME (tumor microenvironment)

Identifiers

PMID42440946
PMCPMC13334205

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.