Evidence mapPaperPMID 42440998Full record

ArticleRSC advances2026

Eudragit S100-coated microbeads of thiolated chitosan/casein for pH-responsive colon-targeted delivery of 6-mercaptopurine.

Huma Hameed, Syed Muhammad Ahmad, Shazia Akram Ghumman, Ali Irfan, Hafiz Shoaib Sarwar, Yousef A Bin Jardan

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huma HameedFaculty of Pharmaceutical Sciences, University of Central Punjab (UCP) Lahore 54000 Pakistan huma.hameed@ucp.edu.pk Shoaib.sarwar@ucp.edu.pk.ORCID https://orcid.org/0000-0002-8636-8644
Syed Muhammad AhmadDepartment of Pharmaceutics, Graduate School of Biomedical Sciences, Nagasaki University 1-7-1 Sakamoto Nagasaki 852-8501 Japan bb55625081@ms.nagasaki-u.ac.jp.ORCID https://orcid.org/0009-0004-4120-084X
Shazia Akram GhummanCollege of Pharmacy, University of Sargodha Sargodha-40100 Pakistan shazia.akram@uos.edu.pk.ORCID https://orcid.org/0000-0002-9631-0243
Ali IrfanDepartment of Chemistry, Government College University Faisalabad Faisalabad-38000 Pakistan raialiirfan@gmail.com.ORCID https://orcid.org/0000-0002-8977-3303
Hafiz Shoaib SarwarFaculty of Pharmaceutical Sciences, University of Central Punjab (UCP) Lahore 54000 Pakistan huma.hameed@ucp.edu.pk Shoaib.sarwar@ucp.edu.pk.
Yousef A Bin JardanDepartment of Pharmaceutics, College of Pharmacy, King Saud University Riyadh 11451 Saudi Arabia ybinjardan@ksu.edu.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

6-Mercaptopurine (6-MP) is a potent chemotherapeutic and immunosuppressive agent; however, its oral administration is limited by poor bioavailability and dose-dependent hepatotoxicity. This study aimed to develop and optimize a colon-targeted, pH-responsive delivery system for 6-MP using Eudragit S100-coated thiolated chitosan/casein microbeads (Eu-S100@TCh/CS) to enhance site-specific release and minimize systemic exposure. The microbeads were fabricated

Identifiers

PMID42440998
PMCPMC13334547

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.