Ultrasound-programmable adhesive hydrogel platform for sequential treatment of infected wounds.

Chenhui He, Linrong Shi, Jiahao Shen, Hengyu Liu, Jiayue Li, Yang Liu, Liang Bai, Daocheng Wu, Mingxi Wan, Yi Feng

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenhui HeThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Linrong ShiThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Jiahao ShenThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Hengyu LiuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Jiayue LiThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Yang LiuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Liang BaiThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Daocheng WuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Mingxi WanThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Yi FengThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic infected wounds remain a clinical challenge to treat due to persistent bacterial colonization, heterogeneous healing microenvironments, and antibiotic resistance. Here, we developed an ultrasound-programmable adhesive hydrogel platform that sequentially coordinates tissue adhesion, transdermal nanoparticle delivery, sonodynamic activation, and tissue regeneration within an integrated therapeutic cascade. Amino-functionalized N-doped graphene quantum dots (aN-GQDs)-modified ZIF-8 nanocomposites (ZIF-8@aN-GQDs) were embedded within a polyacrylamide/alginate hydrogel (PA-ZA). Programmed kHz- and MHz-frequency ultrasound enables non-chemical tissue adhesion followed by transdermal delivery of ZIF-8@aN-GQDs with sonodynamic ROS generation for antibacterial activity. PA-ZA exhibited favorable biocompatibility and promoted cell migration and angiogenesis

Identifiers

PMID42441275

DOI10.1016/j.mtbio.2026.103361

PMCPMC13334979

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.