Evidence map›Paper›PMID 42442355›Full record

ArticleCurrent biology : CB2026

Temporally segregated functions for Gfi1 in the development and maintenance of direction selectivity in the vertebrate retina.

Karina Chaudhari, Luis E Guzman-Clavel, Nitya Donthi, Jeffrey Yang, Scott C Harris, Tzu-Huai Lin, Felice A Dunn, Alex L Kolodkin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Karina ChaudhariSolomon H. Snyder Department of Neuroscience, The Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, CMSC South, Level 8, Suite 8105, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Luis E Guzman-ClavelSolomon H. Snyder Department of Neuroscience, The Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, CMSC South, Level 8, Suite 8105, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Nitya DonthiSolomon H. Snyder Department of Neuroscience, The Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, CMSC South, Level 8, Suite 8105, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Jeffrey YangNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94158, USA.
Scott C HarrisNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94158, USA.
Tzu-Huai LinSolomon H. Snyder Department of Neuroscience, The Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, CMSC South, Level 8, Suite 8105, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Felice A DunnDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA 94158, USA.
Alex L KolodkinSolomon H. Snyder Department of Neuroscience, The Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, CMSC South, Level 8, Suite 8105, 600 N. Wolfe Street, Baltimore, MD 21287, USA. Electronic address: kolodkin@jhmi.edu.

Funding

Molecular mechanisms underlying direction-selective circuit assembly and function in the mouse visual systemR01EY032095 · NEI · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2021 to 2025
$2.3M
NEI NIH HHS R01 EY032095
6 · The paper itself

Abstract

Retinal direction selectivity is a vital component of many visual functions, including motion processing and gaze stabilization. Direction selectivity emerges from specialized retinal ganglion cells (RGCs) that encode motion along a single preferred direction. In the mouse retina, direction-selective (DS) RGC (DSGC) subtypes are quite diverse, but little is known about the genetic programs required to generate this diversity. Moreover, it is unclear whether transcription factors that specify distinct DS subtypes play additional roles in their maintenance or maturation. Here, we show that the transcription factor Gfi1 is a conserved regulator of two DSGC subtypes tuned to vertical motion: down ON-type DSGCs (D-oDSGCs) and F-mini ONs. We show that Gfi1 promotes early differentiation of both subtypes but has distinct roles later in their development. In D-oDSGCs, Gfi1 is required postnatally for directing dendritic elaboration, and loss of Gfi1 disrupts D-oDSGC-mediated downward motion-tracking behavior, whereas in F-mini ONs, Gfi1 is required for continued cell survival . These findings reveal shared and divergent temporally segregated functions of Gfi1 in the assembly of retinal DS circuits.

Indexed as

DNA-Binding ProteinsMotion PerceptionRetinaRetinal Ganglion CellsTranscription FactorsAnimalsMiceDNA-Binding ProteinsGfi1 protein, mouseTranscription Factorsaccessory optic systemdendritic morphologydirectional tuningdirection selectivityGfi1optokinetic reflexretinaretinal ganglion cellvisual system

Identifiers

PMID42442355
PMCPMC13386336

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.