Evidence map›Paper›PMID 42443164›Full record

ArticleCell death & disease2026

Lineage-specific Nrf2 signaling orchestrates distinct neuroprotective mechanisms in acute ischemic stroke.

Xiaoxiao Li, Chenchen Xu, Wenxin Xia, Caiyu Yang, Xin Wang, Jianjian Dong, Yongsheng Han

Abstract read
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoxiao LiAnhui University of Chinese Medicine, Hefei, China.
Chenchen XuAnhui University of Chinese Medicine, Hefei, China.
Wenxin XiaAnhui University of Chinese Medicine, Hefei, China.
Caiyu YangAnhui University of Chinese Medicine, Hefei, China.
Xin WangAnhui University of Chinese Medicine, Hefei, China.
Jianjian DongAnhui University of Chinese Medicine, Hefei, China. jjdong@ahtcm.edu.cn.
Yongsheng HanAnhui University of Chinese Medicine, Hefei, China. hyssp@126.com.ORCID http://orcid.org/0000-0002-9292-2584

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82274656
6 · The paper itself

Abstract

Nuclear factor erythroid 2-related factor 2 (Nrf2), a key antioxidant transcription factor, shows neuroprotective potential in ischemic stroke (IS); however, its cell type-specific functions across different neural lineages remain partially understood. This study innovatively employs a comparative knockout paradigm, utilizing neural lineage knockout (Nrf2

Indexed as

Cell LineageIschemic StrokeNeuroprotectionNF-E2-Related Factor 2AnimalsAstrocytesDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutNestinNeuronsSignal TransductionNestinNfe2l2 protein, mouseNF-E2-Related Factor 2

Identifiers

PMID42443164
PMCPMC13645789

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.