High-performance liquid chromatography - diode array detection method validation for amentoflavone-type biflavonoids in five Encephalartos species with potential neuroprotective activity.

Zainab G El-Natory, Hayam S Ahmed, Dalia El Amir, Nada S Abdelwahab, Abeer Moawad

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

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5 authors.

Zainab G El-Natory *Pharmacognosy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt.

Hayam S Ahmed *Pharmacognosy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt.

Dalia El AmirPharmacognosy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt.

Nada S AbdelwahabPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt.

Abeer MoawadPharmacognosy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt. abeer.moawad@pharm.bsu.edu.eg.ORCID 0000-0002-0228-6757

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ginkgo biloba is a well-known food supplement for enhancing memory and is rich in biflavonoids. Biflavonoids are predominant in the Order Cycadales (cycads). Among cycads, five Encephalartos species, E. ferox, E. kisambo, E. laurentianus, E. natalensis, and E. villosus, were selected to assess the neuroprotective potential by estimation of the antioxidant and acetylcholinesterase (AChE) inhibition activities. E. natalensis and E. ferox strongly inhibited AChE (IC

Indexed as

BiflavonoidsNeuroprotective AgentsAcetylcholinesteraseAnimalsAntioxidantsCholinesterase InhibitorsChromatography, High Pressure LiquidPlant ExtractsAcetylcholinesteraseamentoflavoneAntioxidantsBiflavonoidsCholinesterase InhibitorsNeuroprotective AgentsPlant ExtractsAChEAntioxidantEncephalartosHPLCTotal flavonoidTotal phenolic

Identifiers

PMID42443245

DOI10.1038/s41598-026-60998-6

PMCPMC13365601

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