Evidence map›Paper›PMID 42443461›Full record

ReviewNature reviews. Neuroscience2026

Brain mitochondria as key drivers of cognition and behaviour.

Carmen Sandi, Mary Kay Lobo, Fiona Hollis, Yusuke Hirabayashi, Jaime de Juan-Sanz, Juan P Bolaños

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carmen SandiLaboratory of Behavioral Genetics, Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. carmen.sandi@epfl.ch.ORCID http://orcid.org/0000-0001-7713-8321
Mary Kay LoboDepartment of Neurobiology, Kahlert Institute for Addiction Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Fiona HollisDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, USA.ORCID http://orcid.org/0000-0001-6559-5736
Yusuke HirabayashiDepartment of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0003-3950-6781
Jaime de Juan-SanzInstitut du Cerveau-Paris Brain Institute (ICM), Sorbonne Université, Inserm, CNRS, Hôpital Pitié-Salpêtrière, Paris, France.ORCID http://orcid.org/0000-0002-1212-5623
Juan P BolañosInstitute of Functional Biology and Genomics (IBFG), Universidad de Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0002-3949-6862

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognition and behaviour arise from computations in neural circuits, which can differ in their readiness for recruitment or in the computations and behavioural outputs that they generate. Mitochondria contribute to both circuit properties and their variability by shaping the cellular processes on which circuit function depends. Across neurons and glia, mitochondria provide bioenergetic support, regulate Ca

Indexed as

BehaviorBrainCognitionMitochondriaAnimalsHumansNeuronal PlasticityNeurons

Identifiers

PMID42443461

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.