ArticleDoklady. Biochemistry and biophysics2026
The Proteins of the TREX-2 mRNA Export Complex Are Involved in Anchoring of the Sgf11 Protein Localized in Proximity to the Nuclear Pore in Drosophila melanogaster.
Article in Doklady. Biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The SAGA complex is an important player in the regulation of eukaryotic gene transcription. The interaction of SAGA with the TREX-2 mRNA nuclear export complex makes it possible to efficiently transcribe and export mRNA at loci of actively transcribed genes near nuclear pores. However, it remains unclear whether TREX-2 is involved in anchoring the SAGA complex to the nuclear pore. In this work, we investigated the effect of knockdown of the TREX-2 complex subunits, ENY2 and Xmas-2, on the localization of the SAGA catalytic subunit, histone acetyltransferase Gcn5, in Drosophila melanogaster. The effect of knockdown on the distribution of Sgf11, a component of the SAGA deubiquitinating module, and an mRNP particle component, was also studied. We demonstrated that knockdown of ENY2 and Xmas-2 does not affect the localization of Gcn5 and Sgf11 in proximity to the nuclear pore. Therefore, TREX-2 is not required for the association of SAGA with the nuclear pore. Meanwhile, knockdown of ENY2 and Xmas-2 results in nuclear accumulation of Sgf11, suggesting that TREX-2 is involved in the localization of the SAGA-independent fraction of Sgf11 that participates in mRNA export within the mRNP particle.
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