Trial reportBMC oral health2026
Investigating the effectiveness of N-acetyl cysteine mouthwash in preventing chemotherapy-induced oral mucositis: a randomized, double-blind controlled trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMore than 75% of high-risk individuals experience oral mucositis as a side effect of head, neck, and oral radiotherapy and chemotherapy. The chemical N-acetyl cysteine (NAC) has substantial antioxidant, anti-inflammatory, and antibacterial properties. The goal of this study was to determine the effectiveness of NAC mouthwash in preventing chemotherapy-induced oral mucositis. MATERIALS AND
methodsIn the current randomized, double-blind controlled trial, 68 patients were randomly divided into two groups (34 patients in the intervention group and 34 patients in the control group). The recommended therapeutic dose was 1.25% NAC mouthwash. In this 14-day study, the patients were instructed to use the NAC mouthwash twice daily (15 milliliters each dose). The oral mucosa was evaluated on days 1,7, and 14 following the initiation of chemotherapy and the score was documented based on observation.
resultsOn the 7
conclusionAccording to the results, NAC mouthwash leads to a decrease in the severity of mucositis caused by chemotherapy. It seems that it can be effective as a treatment and preventive medicine for mucositis. CLINICAL RELEVANCE: According to the findings, NAC mouthwash lessens mucositis severity and may help to prevent its onset.
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