Evidence map›Paper›PMID 42443964›Full record

ReviewJournal of translational medicine2026

Metal-phenolic networks: a promising strategy for cancer immunotherapy.

Menglei Wang, Xuefeng Li, Zheyuan Xu, Yang Wang, Yiru Zheng, Aoxiang Li, Lingnan Chen, Meiqi Zhao, Daowei Ding, Xuming Ji

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Menglei Wang *School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Xuefeng Li *The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Zheyuan Xu *School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Yang WangSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Yiru ZhengThe First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Aoxiang LiSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Lingnan ChenSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Meiqi ZhaoSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Daowei DingSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Xuming JiSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China. jixuming724@163.com.

Funding

National Natural Science Foundation of China 82274406 and 82474385Natural Science Foundation of Zhejiang Province LZ24H270001Zhejiang Chinese Medical University Postgraduate Scientific Research Fund Project 2025YKJ03
6 · The paper itself

Abstract

Cancer immunotherapy has revolutionized oncology, yet its clinical efficacy remains constrained by the immunosuppressive tumor microenvironment, poor immune cell infiltration, low tumor immunogenicity, and inefficient delivery of immunomodulators. Metal-phenolic networks (MPNs), coordination assemblies formed from polyphenolic ligands and metal ions, have attracted increasing interest for their dual role in integrating material-intrinsic immune modulation with drug delivery. Metal ions such as Mn²⁺ and Fe²⁺ mediate context‑dependent immune regulation. Mn²⁺ boosts cGAS‑STING activation by enhancing dsDNA sensing and cGAMP‑STING interactions, while Fe

Indexed as

ImmunotherapyMetalsNeoplasmsPhenolsAnimalsHumansMetalsPhenolsCancer immunotherapyImmunogenic cell deathMetal-phenolic networksNanomedicinesNanotechnologyTumor microenvironment

Identifiers

PMID42443964
PMCPMC13556004

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.