Evidence map›Paper›PMID 42444025›Full record

ArticleRedox report : communications in free radical research2026

DMAMCL induces ferroptosis in neuroblastoma by targeting HMOX1 in MYCN-amplified subtypes whereas targeting STEAP3 in MYCN-nonamplified subtypes.

Yifan Ma, Simeng Zhang, Dongyang Zhang, Zhongyan Hua, Zhijie Li

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Article in Redox report : communications in free radical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yifan MaDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Simeng ZhangDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Dongyang ZhangDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Zhongyan HuaDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Zhijie LiDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNeuroblastoma (NB) is a common pediatric extracranial solid tumor. Dimethylaminomicheliolide (DMAMCL), a prodrug of Micheliolide (MCL), shows antitumor activity against NB, but its mechanisms remain unclear. This study investigated the antitumor mechanisms of DMAMCL in NB.

methodsKey pathways/genes were identified by RNA-seq and ferroptosis PCR array. Ferroptosis was confirmed by indicators. Mechanisms were investigated using siRNAs, shRNAs, and overexpression plasmids

resultsDMAMCL induced ferroptosis in NB DISSCUSION: DMAMCL induces ferroptosis in NB through MYCN-associated dual pathways, activating the NRF2/HMOX1 axis via KEAP1 binding in

Indexed as

FerroptosisHeme Oxygenase-1Membrane ProteinsNeuroblastomaN-Myc Proto-Oncogene ProteinOxidoreductasesAnimalsCell Line, TumorHumansKelch-Like ECH-Associated Protein 1MiceNF-E2-Related Factor 2Heme Oxygenase-1HMOX1 protein, humanKelch-Like ECH-Associated Protein 1Membrane ProteinsMYCN protein, humanNF-E2-Related Factor 2N-Myc Proto-Oncogene ProteinOxidoreductasesDMAMCLferroptosisHMOX1MYCNNeuroblastomaSTEAP3, KEAP1, NRF2

Identifiers

PMID42444025
PMCPMC13371481

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.