Evidence map›Paper›PMID 42444292›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Discovery of a novel STING-binding peptide associated with reduced cGAMP-induced inflammatory gene expression.

Junling Lu, Rui Dong, Shudan Yang, Xinyu Yuan, Gang Wang, Jun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junling LuDepartment of Emergency, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, China.
Rui DongDepartment of Emergency, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, China.
Shudan YangDepartment of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, Jiangsu, China.
Xinyu YuanDepartment of Emergency, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, China.
Gang WangDepartment of Emergency, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, China.
Jun WangDepartment of Emergency, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

cGAMP-induced STING activation contributes to inflammatory and interferon-related signalling, making STING a relevant target for inhibitor development. In this study, a 59,319-sequence peptide library was screened against STING by molecular docking, and four top-ranked peptides were selected for evaluation. MST analysis demonstrated that Peptides 1-4 bound to recombinant STING, with Peptide-1 showing the highest affinity (

Indexed as

Drug DiscoveryInflammationMembrane ProteinsNucleotides, CyclicPeptidesAnimalscGAS-STING Signaling PathwayDose-Response Relationship, DrugHumansInterferon-betaInterferon Regulatory Factor-3Interleukin-6MiceMolecular Docking SimulationMolecular StructureRAW 264.7 Cellscyclic guanosine monophosphate-adenosine monophosphateInterferon-betaInterferon Regulatory Factor-3Interleukin-6Membrane ProteinsNucleotides, CyclicPeptidesSTING1 protein, humanSting1 protein, mouseSTING Proteininflammationinhibitormolecular dockingPeptideSTING

Identifiers

PMID42444292
PMCPMC13390157

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.